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In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]

therefore, it must be obtained from diet or supplements

Depending on the reason for the deficiency, the individual may need to take vitamin B12 treatment for their whole lives or until their vitamin B12 levels return to normal

Bile and fat which are trapped can lead to slowing down of the metabolism

Once again, the research doesnt show any additional benefits in these areas either (17)