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Release of organic material can also occur in the form of vesicles that shuttle diverse compounds and enzymes, thereby supporting the growth of heterotrophic bacteria or facilitating viral infection 15,16,17

In a study involving 54 cervical cancer samples, the expression levels of PHGDH were measured, and its association with clinical pathological parameters and patient prognosis was assessed

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This adaptation of tumor cells to hypoxia contributes to the malignant phenotype and to aggressive tumor progression [231], and low oxygen tension in tumors is associated with increased metastasis and poor survival of patients with several forms of squamous tumor [232, 233]

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