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Chronic interstitial nephritis is related to the long-term use of some anti-cancer drugs, analgesics, and calcineurin inhibitors

No human dose has been established and no human trials exist

Inclusion criteria prioritized mechanistic studies, preclinical and clinical trials, and high-quality reviews with explicit senescence-related endpoints, while those excluded were conference abstracts, editorials, and studies lacking primary data on senescence modulation

Sleep and thermoregulation Many previous studies in humans indicate that sleep is strongly linked to thermoregulation (For examples, see [1,6]), which is primarily controlled by circadian rhythm and sleep regulation

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