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Where a single high-dose oral vitamin D3 supplementation in conjunction with antibiotic treatment was found to be effective in reducing the occurrence of repeated pneumonia episodes in a double-blind, placebo-controlled trial involving 453 children aged 136 months who were diagnosed with either non-severe or severe pneumonia at an inner-city hospital in Kabul [56]

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This triggers widespread inflammation, with trauma-induced mitochondrial DAMPs further intensifying oxidative stress and contributing to a sepsis-like state [22,25,26,27]

In rodent models of T1D, intestinal permeability or the leakiness of the gut has been studied by measuring the amount of disaccharides and monosaccharides in the urine following their oral administration
