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Immunohistochemical analysis of endometrial tissues from PCOS patients revealed an increase in the presence of endometrial inflammatory cells, including macrophages, iDCs, mature dendritic cells (mDCs), and CD8 + T cells (57)
Long-term use may lead to reduced efficacy and increased adverse effects (Xu et al., 2023)
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However, the Kuceki 2025 study demonstrated significant improvement when combining microneedling with copper peptide formulations, and the biological rationale is strong: copper peptides promote follicle growth through complementary pathways to minoxidil
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