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IGF-1 gene therapy might alleviate hepatocyte premature senescence through regulating the p53/progerin pathway, to improve hepatic steatosis and fibrogenesis

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These cytokines play a role in the regulation of cellular and subcellular communication and maintain equilibrium with other anti-inflammatory cytokines, including IL-10, IL-4, IL-13, and TGF-, reducing their potential harm [32, 33]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Dickerhof N., Pearson J.F., Hoskin T.S., Berry L.J., Turner R., Sly P.D., Kettle A.J., Arest C.F