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In further studies, silymarin significantly decreased IL-2 and interferon gamma (IFN-) production and blocked nuclear translocation of transcription factor B (NF-B) which activates IL-2 transcription

However, Se has a narrow range of safety intake, because of the risk of acute and chronic toxicity (selenosis) and its potential carcinogenicity (51)

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3 Clinical and Environmental Toxicity Chapter 3 Clinical and Environmental Toxicity is a compilation of Chapter 4, Drug Toxicity and Poisoning and Chapter 67 Environmental Toxicology: Carcinogens and Heavy Metals from Goodman & Gilmans The Pharmacological Basis of Therapeutics , 12th Edition
