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This complex epigenetically regulates gene expression by decreasing histone 2 A ubiquitination (H2Aub) on chromatin in nucleosomes [66,67,68,69,70,71]

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Researchers found that metformin could regulate endometrial tolerance by increasing endometrial glucose transporter protein 4 (GLUT4) expression, modulating the expression of related hormone receptors to affect endometrial transformation, modifying autophagy, as well as modulating DNA/histone modifications and micro RNAs (miRNAs) for transcriptional regulation