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They look across multiple unconnected sources (unconnected is important, so youre not just stuck in an echo chamber) and see how many voices might be saying the same thing

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Khan W, Ajmal Khan M, Khan B, Amin A, Ali M, Farid A, et al

MDPI PubMed 6

This represents a critical knowledge gap

The Sikiric research group has noted across multiple publications the absence of a documented LD50 across oral BPC-157 administration studies in rodent models a finding attributed to the peptides endogenous origin from a protective gastric juice protein rather than a designed synthetic xenobiotic