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In addition, the substrate and product of glutaminase reaction, glutamine and glutamate, respectively, can work as signalling molecules moderating redox and bioenergetic pathways in cancer

In conclusion, we describe that SLC27A5 serves as a suppressor in sorafenib resistance and promotes sorafenib-triggered ferroptosis via restraining the NRF2/GSR pathway in HCC, providing a potential therapeutic strategy for overcoming sorafenib resistance.

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The latter describes hepatic injury arising as a direct toxic effect of administered drugs or their ...

Targeted drug delivery systems using tiny, non-toxic guiding molecules could transform cancer treatment and reduce chemotherapy resistance