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In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

TABLE 2 Drugs and compounds based on System X c /GSH/GPX4 for treatment of drug-resistant solid tumors

10.3389/fneur.2023.1286539 50 MacfarlaneG

London: IntechOpen (2024)

Mechanisms of association between UPF intake and ASD There have been a range of recent studies that have shown that high dietary intake of UPF may contribute to an increased risk of developing ASD, which may be mediated through a range of different pathophysiological mechanisms, including lipid dysregulation, oxidative stress and neuroinflammation (Table 2)