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This fibrotic stroma not only corrals tumor cells into nests but also creates a high-pressure physical barrier that hinders the penetration of therapeutic agents and immune cells [95, 96]

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Also the kill intervention in our approach is HIV-1 specific, because it contains the HIV-1 5LTR as a promoter, the Rev-response element and two HIV-1 inhibitory sequences (INS) of the HIV-1 gag gene

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The stack itself has no clinical validation