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This controlled mitochondrial handling of Ca 2+ supports metabolic output and enables soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) and their proteins (syntaxin-2/11, SNAP-23, VAMP-7/8) mediated graded -granule exocytosis necessary for platelet plug stabilization without producing excess thrombus (Pokrovskaya et al., 2018)

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These metabolic alterations provide a mechanistic link between chronic alcohol consumption and the development or exacerbation of acne, suggesting new therapeutic targets for acne vulgaris in individuals with alcohol use disorder [116]

47 SanjayC.PatilK.NagabhushanaD.PandaR.MahimaV

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The existing literature consistently reports a remarkably wide therapeutic window with minimal observed toxicity even at doses significantly exceeding those used in efficacy studies