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Description
Combined with the RMSD analysis, it can be inferred that after the fluctuation in the first 200 ns, the conformation of CME_b undergoes changes, making it more similar to the characteristics of CME_a.In the CME_c binding mode, the L1 and L4 regions exhibit significant fluctuations during the simulation (Fig

In addition, the cellular antioxidant defense system was further enhanced by up-regulating the expression of mitochondrial uncoupling proteins 4 and 5, which effectively protected the properties of neuronal cells (Peiran et al., 2017)

In case of mutations affecting the function of the bile salt transporter, but especially when the FGF19-driven negative feedback pathway is defective, this leads to bile acid diarrhea type 2 (168)

We chose multidrug resistance protein 1 (MRP1) activity as a test case

CONCLUSION The intricate and bidirectional relationship between the endocrine system and liver function is increasingly recognized as a critical aspect of systemic health

Stress hormones were also found to exert their pro-tumorigenic actions through the modulation of several non-coding mRNAs [226, 227]
