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Ding L., Chang M., Guo Y., Zhang L., Xue C., Yanagita T., Zhang T., Wang Y

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Excessive intracellular accumulation of selenium is toxic to most microorganisms

In two of the OPM-2 xenografts, BSO+L-PAM reduced tumor volumes of 1330 mm 3 and 972 mm 3 to 2), inducing CRs in majority of the mice treated (21/25), achieving MCRs in 6/25 mice, and doubling the median EFS relative to L-PAM alone ( P 80% was not cytotoxic, whereas three cell lines were affected by BSO

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Consequently, decreased mPR3 levels resulted in reduced PR3-ANCAinduced neutrophil activation