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A is generated by proteolytic cleavage from the amyloid precursor protein (APP), a process carried by the - and -secretases (Selkoe and Hardy, 2016)

Adverse effects associated with treatment of dyslipidaemia/statin intolerance Statin intolerance is a phenomenon that has been observed for years, but the interest in it in recent years is associated with the introduction of new agents in combination therapy (PCSK9 inhibitors, inclisiran, and bempedoic acid) (Section 9.10)

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