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conducted an open-label randomized controlled trial (N = 83 LOE3a) in which 200 mg/kg LC was administered daily

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Autophagy was first identified in the 1850s and named in 1963 by de Duve et al ( Autophagy is intricately associated with the clearance of organelles and, more significantly, plays a crucial part in the development and progression of various diseases

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Low-dose naltrexone has shown beneficial effects when compared against a placebo after 12 weeks of treatment, with a mean difference of 0.34 on a 110 pain scale [45]