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Mitochondrial dysfunction in ME/CFS Mitochondrial dysfunction is implicated as a key pathogenic process in ME/CFS, underpinned by mechanisms involving oxidative and nitrosative stress, immune-inflammatory pathways, and metabolic disturbances

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Conclusion : SAG has more preclinical data supporting liver protection, especially in anti-inflammation and antioxidant pathway activation

GSSG levels were determined using a microplate reader at 450 nm and expressed as ng/mg wet tissue (MyBiosource MBS749109)

Trends Neurosci 33:6775 Hopfner F, Wod M, Hglinger GU, Blaabjerg M, Rsler TW, Kuhlenbumer G, Christensen K, Deuschl G, Pottegrd A (2019) Use of 2-adrenoreceptor agonist and antagonist drugs and risk of Parkinson disease

A blood test is the only reliable way to determine whether B12 is truly the issue