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Studies show sequential treatment with FOXO4-DRI following doxorubicin exposure prevents accumulation of senescent cells and mitigates chemotoxicity without compromising the anti-tumor effects of chemotherapy

The process of ferroptosis, mediated by iron overload-induced ROS accumulation, has been shown to drive macrophage polarization towards the M1 phenotype through the ROS/acetyl-p53 pathway, thereby enhancing CD8 + T cell infiltration in the TME [119, 120]

PLs may also have the potential to prevent and treat skin aging

R., Chen, A

PeerJ 11 , e15060 (2023)

(Wang et al., 2020
