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Peripheral BDNF is primarily released from skeletal muscle and platelets through exercise and then transported across the BBB via LRP-1 receptors where it influences BDNF central pathways in the hippocampus and motor cortex [212]

A 2016 study published in Nature Medicine demonstrated that MOTS-c administration improved insulin sensitivity and reduced diet-induced obesity in mouse models, even when started after metabolic dysfunction was already established

Functional Foods and Nutraceuticals [Internet]

R.AltJ.RaisR.WangS

Additionally, copper overload may trigger the opening of the mitochondrial permeability transition pore and cause the release of pro-apoptotic factors, ultimately resulting in cell death [135]

455 Also, the administration of curcuminoids with glycosaminoglycans in osteoarthritis decreased pain and joint stiffness