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These factors contribute to mitochondrial dysfunction and cognitive impairment in affected individuals ( 5.3 Manifestations of neuropsychiatric system injury Ketamine abuse commonly manifests as dissociative symptoms, such as altered consciousness, detachment from the environment, and sensory loss ( 5.4 Auxiliary examination Neuroimaging studies have provided critical insights into ketamine-induced neurotoxicity

Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a key role in energy production, red blood cell formation, and neurological function

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Subsequently, lipid peroxidation promoted the activation of IB kinase- (IKK)/NF-B, which further mediated chronic inflammation and impaired insulin signaling by inhibiting insulin-stimulated phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB) activities (53)

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