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Reduced breakdown of encephalins results in increased levels of endorphins in the brain

Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

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This is because your dose is relatively small, so the time it takes to inject isn't a problem, and the medicine itself is not thick or viscous, so it easily flows through a smaller needle

Pothu UK, Thammisetty AK, Nelakuditi LK (2019) Evaluation of cholinesterase and lipid profile levels in chronic pesticide exposed persons