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2) Under conditions of sustained systemic inflammation (as seen in PEM), high levels of circulating cytokines may degrade tight junction proteins (e.g., claudin-5 and occludin), leading to BBB disruption and increased paracellular permeability
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[DOI] [PMC free article] [PubMed] [Google Scholar] Wang H, Su W, Mu Yet al
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(eds) Ferroptosis in Health and Disease
