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Significance of autophagy in pathology Many studies uncovered dysfunctional mechanisms of autophagy occurring in various diseases
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Of note, in melanoma and ovarian mouse models, CD8 + T cells, when activated by anti-PD-L1 antibody, have been found to drive tumor cell lipid peroxidation and ferroptosis, and this enhanced ferroptosis can promote the anti-tumor function of immunotherapy in turn [223]
