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The reduced folate supply is also linked to impaired nucleotide incorporation and inhibited DNA repair [48,49,50]
doi: 10.3168/jds.2012-6005 22 BrazC
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It is important to note that ITCs exhibit a hormetic dose-response: low dietary doses may have negligible or even protective effects on cells, whereas higher pharmacological doses are required for cytotoxic antitumor activity (113)
DrugBank lists various GST inhibitors (Table 2) that are in investigational, experimental stage or approved by the US FDA
