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Excessive B12 can cause restlessness or a sudden spike in alertness in sensitive individuals

doi: 10.1146/annurev.nutr.18.1.39 59 CaspiRAltmanTDreherKFulcherCASubhravetiPKeselerIMet al

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This well explains how AtCLCa senses the ATP/AMP status to regulate the physiological nitrogen-carbon balance
