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doi: 10.3390/pharmaceutics16030397

10.1161/JAHA.115.002621 [DOI] [PMC free article] [PubMed] [Google Scholar] 224.Zaric BL, Radovanovic JN, Gluvic Z, Stewart AJ, Essack M, Motwalli O, et al

doi:10.1021/es060810w

On the surface, they may sound similar, but they work in different ways and can produce different results

Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides

Although the cerebrovascular system plays an important protective role in maintaining the internal environment balance necessary for neuronal function, the BBB also prevents the entry of drugs, making CNS diseases more difficult to treat than those that can be reached by the systemic circulation
