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Functional and integrative medicine approaches rosacea as a systemic inflammatory condition involving: Gut dysfunction Immune dysregulation Histamine signaling Mast cell activation Neurovascular instability Skin barrier impairment Comprehensive treatment may include: Gut healing strategies Histamine support and DAO Microbiome restoration Anti-inflammatory nutrition Stress and cortisol regulation Advanced peptide therapies LL-37, KPV, and GLOW-based approaches may provide additional support for immune regulation, tissue recovery, and inflammatory balance when used within a broader clinical framework

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Oberheim, C

At the same time, DHA also upregulates the activity of the stress kinase p38 MAPK and increases the level of ROS in tumor cells, triggering the apoptotic program of these cells (61)