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Topical applications are often once or twice daily, while injectable protocols might be daily or every other day

So far, it is hypothesized that (1) on-line benefits to stimulation might be the result of directly modulating Purkinje neuron activity, whereas off-line benefits may be the result from long-lasting changes to the activity of Golgi cells [267, 268], and (2) severe cerebellar atrophy with a major loss of neurons above a threshold is unlikely to respond well to non-invasive stimulation

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Shoot for 7 to 9 hours per night and consistent bedtimes