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Comprehensive toxicology evaluations reveal that the compound does not affect food intake, body temperature regulation, or basic physiological parameters at effective doses in animal models, indicating that its metabolic effects occur through specific pathway modulation rather than general physiological disruption

Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, Hallur MS, Kristam R, Pieper MP
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If these develop, ultrasound evaluation is necessary

Western blot Total protein extracts from macrophages (1 10 6 cells) were prepared using RIPA lysis buffer containing protease and phosphatase inhibitors (Thermo Fisher Scientific)
