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Peer review Peer review information Nature Reviews Chemistry thanks Huaimin Wang and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

But in practice, and especially with regard to synthetic and recombinant peptide forms, there are some considerable potential safety concerns: Immunogenicity Most notably, per a 2020 assessment on therapeutic peptide safety, synthetic and recombinant peptides pose the risk of immunogenicity the ability of a substance to provoke an immune response.15 An immunogenicity-inducing peptide, when introduced to the body, would cause the bodys immune system to perceive the peptide not as a medication but as a threat

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Rather than taking 2,000 mg all at once, splitting the dose into 500 mg or 1,000 mg increments taken with meals throughout the day maximizes absorption and maintains steady plasma levels

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