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About 50% of the histamine in the brain is from mast cells.[ref] Diphenhydramine (Benadryl) has the side effect of making people sleepy due to blocking the actions of histamine in the brain

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[DOI] [PMC free article] [PubMed] [Google Scholar] 202.Zivanovic-Posilovic G., Balenovic D., Barisic I., Strinic D., Stambolija V., Udovicic M., Uzun S., Drmic D., Vlainic J., Bencic M.L., et al

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In tendon-cell work, the peptide has been associated with upregulation of the growth-hormone receptor on fibroblasts, potentially sensitizing healing tissue to circulating growth signals