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The way you get that B-12 matters just as much as how much you take

Hydroxy B12 shots will be safer

The concern is prolonged high-dose supplementation without medical advice, or a blood test showing persistently high B12 when someone is not taking supplements

Whatever system you choose, make it consistent

Yong He, MD1

In the Billon 2023 paper, mice given 30 mg/kg IP still showed measurable plasma and muscle concentrations at 6 hours post-injection, which helps explain why twice-daily dosing was used in efficacy studies
