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Here we describe a study designed to characterise conjugates that form between heme and glutathione

The integrated PK-PD findings, including nonlinear exposure, target tissue accumulation, and disruption of L-carnitine homeostasis, collectively elucidate mildronates mechanism of action through energy substrate depletion, as well as its intrinsic efficacy-toxicity duality

its contribution is essential in case of phenylalanine deficiency.
