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Here it aids in the transmission of a methyl group to homocysteine from the reaction, 5-methyltetrahydrofolate to tetrahydrofolate, to create 2-amino-4-(methylthio)butanoic acid (methionine)

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An R-based Limma package available via Bioconductor 2.11 was used to generate quantitative methylation values ( -values) to identify regions of differential methylation