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Harlan 2006, Chapter 9 this volume
Resistance mechanisms to these drugs have been identified that result in restoration of AR signalling through gain-of-function AR mutations, upregulation of constitutively active AR splice variants or increased intratumoural androgen biosynthesis
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Further research revealed that FDX1 is a key regulator of copper death and an upstream regulator of protein fatty acylation [186]
A: MT1 activates the cAMP/PKA signaling axis, influences transcriptional responses linked to pigmentation, and can modulate neuroimmune and metabolic signaling in receptor-specific models
& Ecker, J
