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Campsen J, Zimmerman MA, Trotter JF, et al

Saliba AN, El Rassi F, Taher AT
(2023) Reconstruction of reverse transsulfuration pathway enables cysteine biosynthesis and enhnaces resilience to oxidative stress in Chinese Hamster ovary cells

It is expected that this convenient, universal and minimally interfering fluorescent labeling method can be applied to the development of nucleic acid delivery systems and promote the upgrading of RNA drugs
Moreover, due to the fact that payload derivatives from non-cleavable ADCs can kill target cells, non-cleavable linkers can potentially provide a larger therapeutic window compared to cleavable linkers
