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In addition, various other nanoparticles have also been shown to improve the immunosuppressive tumor microenvironment by reducing MDSCs infiltration or decreasing MDSCs activity, such as high-density lipoprotein-like nanoparticles (HDL-NP) can specifically target the high-affinity receptor B-1 scavenger receptor (SCARB1) of spherical high-density lipoprotein (HDL) expressed by MDSCs thereby inhibiting MDSCs activity and enhancing the immune response to cancer and significantly inhibiting tumor growth (131)

After the construction of peptide computer models, an important stage has been the geometrical optimization of their structures by minimizing energy using methods of steepest descent and conjugate gradients

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