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Glycine supplementation lowered plasma triglyceride, hepatic aminotransferases, and the GSG index, a biomarker of MASLD, without changes in body weight, insulin resistance, energy expenditure, or whole-body substrate oxidation rates

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This makes niacinamide the preferred form for long-term supplementation and compounding applications

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This NAD + deficit directly impairs sirtuin activity (SIRT), compromising their regulation of mitochondrial biogenesis via PGC-1, antioxidant defense through FOXO transcription factors, and metabolic adaptation via HIF-1 modulation [106, 107]