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Furthermore, bioavailability and pharmacokinetic limitations remain key barriers, warranting innovation in formulation and delivery technologies

[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Ursini F., Russo E., Pellino G., DAngelo S., Chiaravalloti A., De Sarro G., Manfredini R., De Giorgio R

Granic I, Dolga AM, Nijholt IM, van Dijk G, Eisel UL

Long term safety data is limited, with potential risks including hormone imbalance and immune reactions

In this review, we synthesize the current understanding of how dysregulated copper metabolism and cuproptosis drive the pathogenesis of major cardiovascular conditions, including myocardial ischemia/reperfusion (I/R) injury, anthracycline-induced cardiotoxicity, atherosclerosis, diabetic cardiomyopathy (DCM), and sepsis-induced cardiac dysfunction, through pathways such as mitochondrial dysfunction, oxidative stress, and inflammation

Michael Ruscio is a DC, natural health provider, researcher, and clinician