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Fagius and Berman, 2014), which then led to a more controlled study of 12 women with highly active MS who were treated with natalizumab during the third trimester (Haghikia et al ., 2014)

No studies have examined whether BPC-157 use increases cancer risk, but the concern is biologically plausible

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Li J, Wang Q, Yang Y, Lei C, Yang F, Liang L, Chen C, Xia J, Wang K, Tang N (2019) GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway

The ferroptosis activator RSL-3 and the PI3K/Akt pathway inhibitor LY294002 reversed Neuritins inhibitory effect on ferroptosis, indicating that Neuritin suppresses neuronal ferroptosis via PI3K/Akt pathway activation ( In vitro experiments confirmed that A 25-35 treatment significantly inhibited the activation of the NRF2/SLC7A11/GPX4 signaling pathway in HT22 cells, upregulated the expression of Fe 2+ , TFR1, ACSL4, MDA, and GSSG, and decreased the expression of FTH1, SOD, and GSH, as well as the GSH/GSSG ratio, resulting in dysregulated neuronal iron metabolism, impaired amino acid antioxidant systems, mitochondrial dysfunction, and ferroptosis, which ultimately promoted neuronal injury