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DOI: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-319-44080-4 Online ISBN: 978-3-319-44081-1 eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

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Another TKI, gefitinib (ZD1839, Iressa), which targets the epidermal growth factor receptor (EGFR), has been shown to restrict M.tb replication in both macrophages as well as in the lungs of M.tb -infected mice by promoting the host autophagy pathway through the inhibition of the p38 MAPK signaling pathway activated by EGFR [10]

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Under unstressed conditions, three ER stress sensors (inositol-requiring enzyme 1 (IRE1), PKR like endoplasmic reticulum kinase (PERK), and activating transcription factor 6 (ATF6) (5962)) mainly bind to GRP78(78 kDa glucose-regulated protein), helping to keep it inactive

This antioxidant effect was associated with reduced neuronal apoptosis and cerebral edema