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Here are the specifics for needle size selection for IM injections: Needle Gauge : 22-25 Gauge : The gauge of the needle refers to its thickness

As a result, the biochemical pathway leading to TMAO is not activated

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[DOI] [PMC free article] [PubMed] [Google Scholar] 120.Allan NP, Yamamoto BY, Kunihiro BP, Nunokawa CKL, Rubas NC, Wells RK, Umeda L, Phankitnirundorn K, Torres A, Peres R, Takahashi E, Maunakea AK

In study by Goldstein et al., patients with painful diabetic neuropathy were treated with duloxetine at doses of 60 or 120 mg/day, resulting in pain relief and increased overall quality of life compared to placebo [77]

You can read more about this debate in this article on L-Citrulline vs Citrulline Malate, opens in a new tab
