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doi: 10.1073/pnas.1716173114 39 MoroTEbertSMAdamsCMRasmussenBB

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Mechanisms of action of the new antibodies in use in multiple myeloma

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The methionine cycle consists of 4 substances: Methionine S-adenosylmethionine (SAM) S-adenosyl homocysteine (SAH) Homocysteine The essential task of this cycle is to break down harmful homocysteine and to regenerate it again into the methyl donor S-adenosylmethionine (SAM)

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These polymorphisms are common in the population and can influence homocysteine levels and methylation efficiency

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This preparation is contraindicated in patients who are sensitive to cobalt and/or vitamin B12

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