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Chain elongation (for methionine or phenylalanine): Extends the R-group via condensation, isomerization, and decarboxylation

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Epitalon (Ala-Glu-Asp-Gly) is the synthetic tetrapeptide identified as the shortest active sequence responsible for epithalamin''s observed biological effects, including telomerase activation in cell culture studies

doi: 10.1007/s10067-021-05942-x 108 ChaddaKRBlakeyEEHuangCLHJeevaratnamK

Ferritin-1 ameliorated the decreased cell viability and elevated LDH caused by GPx-4 gene knockout

The reversible reduction of GSSR substrates usually requires only the first active-site cysteinyl residue and is therefore catalyzed by a monothiol mechanism with ping-pong bi-bi kinetic patterns (Fig