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1, 10.1038/s41598-019-40638-y, 2-s2.0-85062883274

We know for every drug thats been approved going through the safety profile, the toxicology, the pharmokinetics that has then been approved in humans, theres just as many, if not more, that have fallen by the wayside along the way because they dont have a specific benefit for whatever it was we were looking to treat, he said

The most frequently mutated genesCDKN2A, TP53, KRAS, and SMAD4currently lack viable pharmacological targets, significantly hindering the development of effective treatment options [6]

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