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From a modern perspective, in Chinese medicine, we would call them the six evils: heat, damp, cold, dryness, things like that

While LifeWave points to clinical studies (see links to two examples in the References section if you want to check them out for yourselves) in support of their X39 patches, the studies I found on these patches in my opinion are not convincing as they were small, had questionable or unclear methods (e.g

[DOI] [PubMed] [Google Scholar] 308.Shaki F., Ashari S., Ahangar N

[DOI] [PubMed] [Google Scholar] 31.Tiedge M., Lortz S., Munday R., Lenzen S

In: Tierney L, McPhee S, Papadakis M, eds

Recent studies have highlighted the role of epigenetic modifications, particularly DNA methylation, in the regulation of gene expression during oocyte maturation and folliculogenesis 6,7