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L-Carnitine is a naturally occurring amino acid derivative involved in normal energy metabolism

Only 12% of an oral crystalline dose of non-protein bound vitamin B12 as occurs in fortified foods and supplements is absorbed by simple passive diffusion throughout the length of the gastrointestinal tract (Doets et al., 2013)

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This is particularly relevant for oral administration, which is subject to intrinsic factor saturation and receptor limitations in the ileum (Paul and Brady, 2017

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