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In patients with chronic coronary syndrome, persistent low-grade inflammation remarkably influences disease prognosis, with hs-CRP serving as an effective marker for assessing this impact (118)

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Neuroprotection Research Investigations in brain injury and neuroinflammation models demonstrated: Enhanced memory formation and consolidation when fused with blood-brain barrier-penetrating peptides Amelioration of memory deficits induced by amyloid-beta or lipopolysaccharide Significant downregulation of hippocampal pro-inflammatory cytokines Potential therapeutic relevance for age-related cognitive decline Critical Research Limitation: Despite extensive animal research spanning metabolic disorders, aging, and physical performance, MOTS-c has NO completed peer-reviewed human clinical trials published in scientific literature

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