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Chronic hepatocyte injury and cell death ultimately lead to inflammatory changes (hepatitis) and net accumulation of extracellular matrix (fibrosis) within the liver

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The main mechanism of ferroptosis Inhibiting the cysteine-glutamate transporter system Xc can induce ferroptosis System Xc is a sodium independent antiporter that export intracellular glutamate and import extracellular cystine across the membrane in a ratio of 1:1 to synthesize glutathione in cells [19]

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